Tadafumi Kato, MD, PhD Degree:Ph.D. (Shiga University of Medical Science)
M.D. (The University of Tokyo) Tadafumi Kato, MD, PhD | RIKEN Center for Brain Science - Lab. for Molecular Dynamics of Mental Disorders

Tadafumi Kato, MD, PhD | RIKEN Center for Brain Science - Lab. for Molecular Dynamics of Mental Disorders

Research Interest

He is studying the causes of bipolar disorder to develop new diagnostic methods and treatments. Major strategies include genome analysis, cellular models, animal models, and postmortem brain analyses. He is aiming at bridging basic and clinical researchers by combining comprehensive neurogenomics and hypothesis driven researchs.

Profile

1988
Graduated from Faculty of Medicine, University of Tokyo
1989-1997
Shiga Univ. of Medical Science, Research Associate of Psychiatry
1994-1995
International Visiting Fellow, University of Iowa, Department of Psychiatry
1997-1999
University of Tokyo, Faculty of Medicine, Research Associate of Neuropsychiatry
1999-2000
University of Tokyo, Faculty of Medicine, Lecturer of Neuropsychiatry
2001-2018
Team Leader, Lab. for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute
2018–Present
Team Leader, Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science
2018–Present
Director, Research Resources Division, RIKEN Center for Brain Science
2018–Present
Professor, Coordinate Department of Brain Functional Dynamics, Faculty of Medicine, University of Tokyo

Psychiatry and Clinical Neuroscience (Editor-in-Chief）

Honors and Awards

2019
Mogens Schou Award for Research, International Society for Bipolar Disorders
2017
Colvin Prize, Brain and Behavior Foundation
2014
Tsukahara Memorial Award, Brain Science Foundation
2008
NARSAD Independent Investigator’s Award
1998
CINP Rafaelson Fellowship Award
1995
Stanley Foundation Research Award
1995
Academic Prize of Japanese Society of Biological Psychiatry

Selected publications

  1. Kato TM#, Kubota-Sakashita M#, Fujimori-Tonou N#, Saitow F, Fuke S, Masuda A, Itohara S, Suzuki H, Kato T* (2018). Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder. Molecular Psychiatry June 11/2018
  2. Takata A*, Matsumoto N, Kato T* (2017) Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci. Nature Communications 8: 14519
  3. Kataoka M#, Matoba N#, Sawada T, Kazuno AA, Ishiwata M, Fujii K, Matsuo K, Takata A*, Kato T* (2016) Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations. Molecular Psychiatry 21: 885-893
  4. Kasahara T#, Takata A#, Kato TM#, Kubota-Sakashita M, Sawada T, Kakita A, Mizukami H, Kaneda D, Ozawa K, Kato T* (2016) Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus. Molecular Psychiatry 21: 39-48
  5. Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CE, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ*, Schulze TG* (2016) Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet, 38: 1085-1093
  6. Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T*, Iwamoto K* (2014) Increased L1 retrotransposition in the neuronal genome in schizophrenia. Neuron, 81: 306-313
  7. Iwamoto K*, Bundo M, Ueda J, Oldham MC, Ukai W, Hashimoto E, Saito T, Geschwind DH, Kato T* (2011) Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Research 21: 688-696
  8. Kazuno A, Munakata K, Nagai T, Shimozono S, Tanaka M, Yoneda M, Kato N, Miyawaki A, Kato T* (2006) Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics. PLoS Genetics 2: e128
  9. Iwamoto K, Bundo M, Kato T* (2005) Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Human Molecular Genetics 14: 241-253
  10. Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T* (2003) Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nature Genetics 35: 171-175