Yasuyuki Shima, PhD Degree: Ph.D. in Science, Kyoto University Yasuyuki Shima, PhD | RIKEN Center for Brain Science - Lab. for Molecular Dynamics of Mental Disorders

Yasuyuki Shima, PhD | RIKEN Center for Brain Science - Lab. for Molecular Dynamics of Mental Disorders

Research Interest

The central nervous system has myriad type of neurons (cell types) each of which shows distinct physiological properties and connection patterns. Identification of cell types and cell-type specific functional analyses would give deep insights in the function of a particular region of the brain in normal and disease conditions. My primary research interest is cell types in paraventricular nucleus of the thalamus (PVT) and their functions in mood disorder model mouse. I am using multiple approaches like single cell RNAseq and whole cell physiological recording to address this question. Also I am working on the development of molecular tools for cell-type specific genetic manipulation.

Profile

2012-2017
Research Scientist, Brandeis University
2006-2012
Postdoctoral fellow, Brandeis University
2004-2006
Postdoctoral fellow, Kyoto University

Selected Papers

  1. Distinct projection patterns of different classes of layer 2 principal neurons in the olfactory cortex.
    Mazo C, Grimaud J, Shima Y, Murthy VN, Lau CG.
    Sci Rep. 2017 Aug 15;7(1):8282. doi: 10.1038/s41598-017-08331-0
  2. Dicer maintains the identity and function of proprioceptive sensory neurons.
    O'Toole SM, Ferrer MM, Mekonnen J, Zhang H, Shima Y, Ladle DR, Nelson SB.
    J Neurophysiol. 2017 Mar 1;117(3):1057-1069. doi: 10.1152/jn.00763.2016
  3. Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons.
    Crittenden JR, Tillberg PW, Riad MH, Shima Y, Gerfen CR, Curry J, Housman DE, Nelson SB, Boyden ES, Graybiel AM.
    Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11318-11323
  4. Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.
    Steinmetz CC, Tatavarty V, Sugino K, Shima Y, Joseph A, Lin H, Rutlin M, Lambo M, Hempel CM, Okaty BW, Paradis S, Nelson SB, Turrigiano GG.
    Cell Rep. 2016 Sep 6;16(10):2711-2722. doi: 10.1016/j.celrep.2016.08.009
  5. A Mammalian enhancer trap resource for discovering and manipulating neuronal cell types.
    Shima Y, Sugino K, Hempel CM, Shima M, Taneja P, Bullis JB, Mehta S, Lois C, Nelson SB.
    Elife. 2016 Mar 21;5:e13503. doi: 10.7554/eLife.13503